David Sinclair, 2001


    1) TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction.

    Griffin PT, Kane AE, Trapp A, Li J, Arnold M, Poganik JR, Conway RJ, McNamara MS, Meer MV, Hoffman N, Amorim JA, Tian X, MacArthur MR, Mitchell SJ, Mueller AL, Carmody C, Vera DL, Kerepesi C, Ying K, Noren Hooten N, Mitchell JR, Evans MK, Gladyshev VN, Sinclair DA.  Nat Aging. 2024 Jan 10. doi: 10.1038/s43587-023-00555-2. Online ahead of print. PMID: 38200273

    2) Human trials exploring anti-aging medicines.

    Guarente L, Sinclair DA, Kroemer G. Cell Metab. 2023 Dec 22: S1550-4131(23)00458-8. doi: 10.1016/j.cmet.2023.12.007. Online ahead of print. PMID: 38181790 Review.

    3) Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming.

    Cipriano A, Moqri M, Maybury-Lewis SY, Rogers-Hammond R, de Jong TA, Parker A, Rasouli S, Schöler HR, Sinclair DA, Sebastiano V. Nat Aging. 2023 Dec 15. doi: 10.1038/s43587-023-00539-2. Online ahead of print. PMID: 38102454 Review.

    4) The Information Theory of Aging.

    Lu YR, Tian X, Sinclair DA. Nat Aging. 2023 Dec;3(12):1486-1499. doi: 10.1038/s43587-023-00527-6. Epub 2023 Dec 15. PMID: 38102202 Review.

    5) Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma.

    Karg MM, Lu YR, Refaian N, Cameron J, Hoffmann E, Hoppe C, Shirahama S, Shah M, Krasniqi D, Krishnan A, Shrestha M, Guo Y, Cermak JM, Walthier M, Broniowska K, Rosenzweig-Lipson S, Gregory-Ksander M, Sinclair DA, Ksander BR.  Cell Reprogram. 2023 Dec 7. doi: 10.1089/cell.2023.0074. Online ahead of print. PMID: 38060815


    1992  Commonwealth Serum Laboratories (CSL) Prize
    1994  The Thompson Prize
    1992 – 1996  Graduate Research Scholarship
    1996 – 1999  Helen Hay Whitney Postdoctoral Fellowship
    1999 – 2000  Charles Hood Fellowship
    1999 – 2002  Leukemia Society of America Special Fellowship
    2000 – 2001  Ludwig Institute Young Faculty Award
    2000 – 2002  American Federation for Aging Research Fellowship
    2001 – 2005  Ellison Medical Foundation New Scholar Award
    2001 – 2003  Arminese Harvard Junior Faculty Grant, Department of Cancer Biology: “Links Between Silencing, DNA Repair and Aging”, 2001.
    2005  Genzyme Outstanding Achievement in Biomedical Science Award
    2006  Telluride Technology Festival Honoree
    2006  Bright Sparks Award, Australia’s leading scientists under 45
    2006  Excellence in Teaching Award, Harvard Medical School
    2007  Innovator of the Year, BioAgenda Institute
    2007-2011  Ellison Medical Foundation Senior Scholarship
    2008  Merck Prize, University of Alberta, CA
    2008  David Murdock-Dole Lectureship, Australia
    2009- present  Honorary Professorship, University of Sydney, Australia
    2010  Fisher Honorary Lectureship, UCLA
    2010  Nathan Shock Award, NIH
    2010  Firkin Oration, Melbourne, Australian Society of Biochem. Mol. Biol.
    2012  NIH MERIT Award
    2014  Denham Harmon Award for Research in Gerontology
    2014  The Australian Medical Research Medal (ASMR)
    2014  TIME 100 – list of “World’s Most Influential People”
    2015  Frontiers in Aging Research Award
    2015  Knowledge Nation 100, Australia’s 100 top contributors to knowledge economy
    2016  Winner, NASA’s iTech competition, innovative solutions getting to Mars
    2017  Kesten Memorial Lecture (USC)
    2017  Advance Global Australian Award, National Winner
    2017  Royal Academy of New South Wales, Member
    2017  NIH Director’s Pioneer Award
    2018  Irving Wright AFAR Award of Distinction
    2018  TIME 50 – Top People in Healthcare
    2018  Officer of the Order of Australia (AO)
    2021  Director’s Lecture (NIH), WALS
    2023  Award & Lecture, Saunders Endowment for Research in Aging & Geriatric  & Pharmacotherapy

Who he is
David A. Sinclair, A.O., Ph.D. is a tenured Professor in the Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995 and worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999, he moved to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 23 years. His early research was focused on the sirtuins, which are protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in epigenetics, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer.

What he does
Dr. Sinclair’s research is focused primarily on understanding genes that fight disease and aging, with a focus on treating the major causes of death and disability. He studies cellular energy production, learning and memory, neurodegeneration, cancer, and inflammation. More recently his work has branched out to understand why we age and how to reverse it. He has directly mentored over 100 scientists over the past 20 years and won awards for mentorship and teaching. He is co-founder of several biotechnology companies and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in seven books, three documentary movies, 60 Minutes, Morgan Freeman’s “Through the Wormhole” and other media. He is an inventor on over 50 patents and has received more than 35 awards and honors including the CSL Prize, The Australian Commonwealth Prize, Thompson Prize, Helen Hay Whitney Postdoctoral Award, Charles Hood Fellowship, Leukemia Society Fellowship, Ludwig Scholarship, Harvard-Armenise Fellowship, American Association for Aging Research Fellowship, Nathan Shock Award from the National Institutes of Health, Ellison Medical Foundation Junior and Senior Scholar Awards, Merck Prize, Genzyme Outstanding Achievement in Biomedical Science Award, Bio-Innovator Award, David Murdock-Dole Lectureship, Fisher Honorary Lectureship, Les Lazarus Lectureship, Australian Medical Research Medal, The Frontiers in Aging and Regeneration Award, Top 100 Australian Innovators, and TIME magazine’s list of “The Top 50 in Healthcare” and the “100 Most Influential People in the World.”

News from the Lab

The Sinclair lab was the first to identify a role for NAD+ biosynthesis in regulation of lifespan, that sirtuins activated by CR in mammals (A Unified Theory of Caloric Restriction, 2005), the identification of small molecules that activate SIRT1 such as resveratrol, how organisms appear to have evolved to sense plant stress and declining food supply by having plant stress metabolites such as polyphenols activate longevity defenses (The Xenohormesis Hypothesis, 2006), that relocalization of epigenetic factors such as SIRT1 in response to DNA breaks may be a cause of aging (The RCM Hypothesis of Aging, 2008), how miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline (The Mitochondrial Oasis Hypothesis, 2009), and the idea that epigenetic changes causing cells to lose their identify are a main cause of aging and this is a reversible process (The Information Theory of Aging, 2019).


    David Sinclair
    Department of Genetics – Blavatnik Institute
    websiteSinclair Lab